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Gluten Intolerant, Sensitive or Celiac— Is it a trend or immune disorder?

Gluten Intolerant, Sensitive or Celiac— Is it a trend or immune disorder?

Recently, being “Gluten Intolerant” has become a self-diagnosed trend, resulting in individuals cutting gluten from their diet completely. Whether this is from the idea that gluten (a protein found in wheat, rye and barley) is “unhealthy” or someone is experiencing symptoms similar to Celiac Disease found on a Google search, there is a better way to know exactly how your immune system reacts to gluten. We are here to straighten out this guessing game for you, and your doctors that seem to be baffled by your inconclusive tests or list of symptoms.

What if we told you that the answer was inside of you? Not just the painful stomachache you feel after a piece of toast, but in your genetics! Let us explain…

First it is important to note, the term gluten intolerance may refer to three types of human disorders: autoimmune Celiac disease (CD), allergy to wheat and non-celiac gluten sensitivity (NCGS).

  • Autoimmune Celiac Disease is an immune reaction when someone eats gluten, which causes and immune response from the small intestine [1].
  • Allergy to wheat, when the body produces antibodies in reaction to wheat, from eating foods containing wheat and in some cases inhaling wheat flour [2].
  • Non-celiac gluten sensitivity, a condition characterized by symptoms both intestinal and extra-intestinal when gluten is in the diet with the absence of celiac disease or wheat allergy [3].

Who is most likely to have one of these gluten-related conditions?

Celiac Disease, wheat allergy and Non-celiac gluten sensitivity are all at higher risk to those with predisposed genetics to these conditions. If you have a first-degree relative (Parent, child, sibling) with one of these conditions, your risk is higher (1:10).

Common Celiac Disease symptoms to look out for

Most common symptoms found in children:

  • abdominal bloating and pain
  • chronic diarrhea
  • vomiting
  • constipation
  • pale, foul-smelling, or fatty stool
  • iron-deficiency anemia
  • weight loss
  • fatigue
  • irritability and behavioral issues
  • dental enamel defects of the permanent teeth
  • delayed growth and puberty
  • short stature
  • failure to thrive
  • Attention Deficit Hyperactivity Disorder (ADHD)

Most common symptoms found in adults:

  • unexplained iron-deficiency anemia
  • fatigue
  • bone or joint pain
  • arthritis
  • osteoporosis or osteopenia (bone loss)
  • liver and biliary tract disorders (transaminitis, fatty liver, primary sclerosing cholangitis, etc.)
  • depression or anxiety
  • peripheral neuropathy (tingling, numbness or pain in the hands and feet)
  • seizures or migraines
  • missed menstrual periods
  • infertility or recurrent miscarriage
  • canker sores inside the mouth
  • dermatitis herpetiformis (itchy skin rash)

Also, there are cases of asymptomatic celiac disease patients, in which there are no complaints from the individual with CD but there is still evidence of damage to the small intestine [4].

­­­How the DNA ConneXions® gluten sensitivity panel can help you take control of your health BEFORE symptoms occur.

The DNA ConneXions® Gluten Sensitivity test panel utilizes super floss to detect the presence or absence of the HLA tissue typing markers for DQ2 and DQ8 (specifically the markers HLA-DQB1*02, HLA-DQA1*0501, HLA-DQB1*0302 exon2 and HLA-DQB1*0302 exon3). The presence of any of these genetic markers is 95% predictive for gluten intolerance/sensitivity. The presence of all markers is 95% predictive for Celiac disease. Our gluten sensitivity test panel can help you discover health problems and take steps to improve your diet before symptoms occur. 

If you, or someone you know, have a high risk of developing Celiac disease, allergy to wheat, or non-celiac gluten sensitivity, our test panel can provide insight into your genetics to aid you and your doctor in reaching diagnosis.

So is it a Trend? With predictions that 1:100 people and 1:10 of those who have first-degree relatives suffer from celiac disease, this trend is real. The good news is we have the resources to help people discover their likelihood of these conditions and allows those individuals to take the steps to adjust their diets accordingly.

Take control of your health today… Purchase your Gluten Panel HERE.


  1. Mayo Clinic. 2021. “Celiac Disease.” Accessed September 2.
  1. Mayo Clinic. 2020. “Wheat allergy.” Last Modified April 23, 2020.
  1. 2018. “Recent Advances in Understanidng Non-celiac Gluten Sensitivity.”
    Published online 2018 Oct 11. doi: 10.12688/f1000research.15849.1
  1. Celiac Disease Foundation. “Symptoms of Celiac Disease.” Accessed September 2.