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The DNA ConneXions® ApoE Genotyping Test 
The ApoE gene has been significantly linked as a genetic predisposition to Alzheimer’s disease and cognitive development.

Don’t guess. Get the test.®
Knowing your risk factor allows you to take proper measures to mitigate potential health challenges in the future.


Alzheimer’s disease is a form of dementia that is expected to affect over 75 million individuals by 2030 and almost 2 billion by 2050. Evidence-based scientific research has found a link between the Apolipoprotein E (ApoE) gene found on chromosome 19 and Alzheimer’s disease. Individuals inherit two alleles for each gene, one from each parent, and the genetic combination determines your ApoE ”genotype” – E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, E4/E4.

The ApoE4 genetic variant has been associated with:

  • Alzheimer’s Disease
  • Brain atrophy
  • Cardiovascular Disease
  • Poor Immune Response
  • Increased Cholesterol Levels


The Missing Link between Heavy Metals, ApoE, and Alzheimer’s Disease 

Your ApoE genotype can determine how well your body can eliminate heavy metals such as mercury, lead, cadmium, and aluminum. Heavy metal exposure from food, water, air, and mercury dental amalgam fillings can bind to the ApoE protein and can accumulate in the central nervous system leading to various neurodegenerative diseases (Source).

While the optimal genotype for removing heavy metals is ApoE 2/2, ApoE 3/3 is the most common, and the most detrimental genotype is ApoE 4/4. Individuals with ApoE 3/4 or 4/4 have a very difficult time detoxifying mercury or other heavy metals and have an increased propensity to develop Alzheimer’s disease.

The DNA ConneXions® ApoE Genotyping Test can provide insight into your genetics. Knowing your risk factor allows you to take proper measures to mitigate potential health challenges in the future. It is important to remember, a 4/4 ApoE genotype is not a guarantee or diagnosis of Alzheimer’s disease, although it does indicate a marked increase in the propensity to develop the illness. Patients should seek a consultation with a qualified physician or specialist if they possess a high-risk genotype. 

Dr. Blanche Grube, owner/CEO of DNA ConneXions® and a dentist for over 40 years stated, “Evidence-based research has linked exposure to mercury dental amalgams as a significant risk factor for Alzheimer’s disease. The tragedy is that this information is not widely known. This is especially concerning because over half of the United States population has mercury dental amalgam fillings. Not only consumers, but especially those working in the dental field should also take this simple test due to occupational exposure.”

The DNA ConneXions ApoE test panel can be utilized without a doctor’s order and is performed with a simple, non-invasive dental Super Floss in the comfort of your own home.

In support of Alzheimer’s awareness, DNA ConneXions® is offering a 15% discount on our ApoE Test.
Please use code “APOE1122” at checkout thru January 31. Purchase your test HERE.

DNA Connexions® OFFERS five tests utilizing Polymerase Chain Reaction (PCR). This molecular technique amplifies human DNA in order to yield exceedingly sensitive and specific results.

Lyme disease mimics many other diseases and illness. The DNA ConneXions® Lyme Disease Test identifies four different Borrelia species and ten of its common co-infectors.  

Alzheimer’s Disease & Mercury Toxicity 

This genotypic test deter­mines an individual’s ability to detoxify mercury as well as their propensity to develop Alzheimer’s and other autoim­mune/neurological conditions. The DNA ConneXions® ApoE Test can provide insight into your genetics and help you take the steps needed to improve your health. 

The DNA ConneXions® Comprehensive Oral Test identifies foreign microbial DNA of aerobic & anaerobic bacteria, fungi, parasites, and viruses in dental implants, oral blood, tissue, cavitational blood, removed teeth, bone grafts and other biological samples. This test examines 88 microbes in total. 

The DNA ConneXions® Gluten Sensitivity Test can help you discover health problems and take steps to improve your diet. The presence of the genetic markers can be indicative of celiac disease, gluten sensitivity, and/or gluten intolerance. 

Periodontal Diseases & Other Chronic and/or Systemic Conditions

The DNA ConneXions® Propensity Test identifies 19 of the most common species not only involved in periodontal diseases, but also those microbes which have been implicated in the progression of a variety of chronic and systemic conditions.  

Early detection can mean a better response to treatment.

Don't guess. Get the test.®

Early detection can mean a better response to treatment.


Your purchase includes free standard shipping (both ways), lab processing, and a full report with the results of the sample you provide to us. If you would like to have the results of your sample expedited more quickly, please also select Rush Processing.

If you already have a test and need to pay to return your sample, please visit our Return Your Sample page to complete your order.

Ordering from outside of the U.S: DNA ConneXions® can service most international locations. Depending on location, an international shipping fee will be applied to your cart upon checkout.

If you wish to check in advance to ensure feasibility, please email info@ and provide the complete shipping address and our shipping department will make the determination if we can receive your sample back within our transport time frame.

DNA ConneXions® is a Biosafety Level 2 laboratory with a CLIA license encompassing the following specialties:

Bacteriology – Mycology – Virology

Our lab offers accessible DNA testing to practitioners and individuals alike.

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