APOLIPOPROTEIN E GENOTYPE TEST
The DNA ConneXions ApoE Genotyping Test can provide insight into your genetics and help you take the steps needed to improve your health.
It is important to remember, a 4/4 ApoE genotype is not a guarantee or diagnosis of Alzheimer’s disease, although it does indicate a marked increase in the propensity to develop the illness. Patients should seek a consultation with a qualified physician or specialist if they possess a high-risk genotype.
Sampling Method: Super Floss
The DNA ConneXions ApoE Test can be utilized without a doctor’s order and is performed with a simple, non-invasive dental Super Floss in the comfort of your own home.
The ApoE gene has been significantly linked as a genetic predisposition to Alzheimer’s disease and cognitive development.
Apolipoprotein-E (ApoE) is composed of 299 amino acids and transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. It is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen.
In the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of ApoE, while neurons preferentially express the ApoE receptors. There are seven currently identified mammalian receptors for ApoE which belong to the evolutionarily conserved low density lipoprotein receptor gene family.
About Apolopoprotein E
Apolipoprotein E (ApoE) is a class of proteins involved in the metabolism of fats in the body.
This protein combines with fats to form molecules called lipoproteins. Lipoproteins are responsible for packaging cholesterol and other fats and carrying them through the bloodstream.
Maintaining normal levels of cholesterol is essential for the prevention of conditions which affect the heart, blood vessels, hormones and cell membranes.
Since the brain is made of mostly neurons covered with a myelin sheath composed of cholesterol, it follows that the protein portion of these lypoproteins would affect the structure, integrity and functions of all fats in the brain and body.
ApoE Genotypes
Everyone has two copies of the ApoE gene and the genetic combination determines your ApoE “genotype” -E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, E4/E4.
This genotypic test determines an individual’s ability to detoxify mercury as well as their propensity to develop Alzheimer’s and other autoimmune/neurological conditions.
Keep in mind that a persons genetic profile is just that – a “profile” and does not definitively indict a person to any one specific disease. It is commonly understood by scientists and doctors that a persons environmental exposure during their lifetime is just as important, if not more important, than their genetic profile.
The ApoE gene has been significantly linked as a genetic predisposition to Alzheimer’s disease and cognitive development.
The ApoE4 genetic variant has been associated with:
- Brain atrophy
- Alzheimer’s Disease
- Cardiovascular Disease
- Poor Immune Response
- Increased Cholesterol Levels
Genotypes 3/4 and 4/4
People with harmful forms of the ApoE gene (genotype 3/4, 4/4) have up to 12 times the risk of developing Alzheimer’s disease compared with those who have other variations (2/2, 2/3, 3/3) of the gene.
Mercury and ApoE
Another potential role of ApoE is in the removal of mercury from the biosystem.
The optimal genotype for removing mercury is ApoE 2/2 (4 cysteine residues), whereas ApoE 3/3 is the most prevalent in the human population (2 cysteine residues and 2 arginine residues), and the most detrimental is ApoE 4/4 (4 arginines and no mercury removing capability).
Don't guess. Get the test.
About Shipping and Processing
Your purchase includes free standard shipping (both ways), lab processing, and a full report with the results of the sample you provide to us.
Lab Processing: Samples are processed in the order they are received.
Standard Reporting: Standard Reporting time is within 10 business days from the date the sample and payment is received by DNA ConneXions.
Rush Report Processing (optional, $99): Rush Report Processing time is guaranteed within 5 business days from the date the sample and payment is received by DNA ConneXions. You can select Rush Processing option on the Checkout page right before entering your payment information.
PLEASE NOTE THAT WE ARE UNABLE TO ISSUE A REFUND ON PURCHASED TESTS
Important Note Regarding All Tests: In order to return valid test results, it’s critical that directions are followed exactly as they are provided. Failure to do so may yield inaccurate results and a new test will have to be completed. Please be advised that the cost of a new test kit is $50. If you have questions about specimen collection on any of our tests, please visit our FAQ page, or contact us directly: 1-888-843-5832. Thank you!