Questions? (888) 843-5832 


Early detection can mean a better response to treatment.

The DNA ConneXions Gluten Sensitivity Test utilizes super floss to detect the presence or absence of the HLA tissue typing markers for DQ2 and DQ8 (actually the markers HLA-DQB1*02, HLA-DQA1*0501, HLA-DQB1*0302 exon2 and HLA-DQB1*0302 exon3).

The presence of any of these genetic markers is 95% predictive for gluten intolerance and/or sensitivity. The presence of both markers is 95% predictive for celiac disease.

Our Gluten Sensitivity Test can help you discover health problems and take steps to improve your diet. 

Sampling Method: Super Floss

The DNA ConneXions Gluten Sensitivity Test can be utilized without a doctor’s order and is performed with a simple, non-invasive dental Super Floss in the comfort of your own home.

Gluten Sensitivity

Gluten sensitivity is a condition with symptoms similar to those of Celiac disease that improve when gluten is eliminated from the diet. People with gluten sensitivity can experience symptoms such as “foggy mind”, depression, ADHD-like behavior, abdominal pain, bloating, diarrhea, constipation, headaches, joint pain, and chronic fatigue when they have gluten in their diet, but other symptoms are also possible.

Examples may include asthma-like symptoms upon ingestion of gluten, and/or a filling of the sinus cavities with fluid. While these are common symptoms of Celiac disease, these individuals do not test positive for Celiac disease and/or a wheat allergy. The gluten sensitivity test panel can determine whether or not you are at risk for gluten intolerance/sensitivity or celiac disease before symptoms occur.

Cause and Effect

Individuals who have been diagnosed with gluten sensitivity do not experience the small intestine damage or develop the tissue transglutaminase (tTG) autoantibodies found in celiac disease. Triggers such as viruses, bacteria and possibly gluten itself activate professional antigen-presenting cells, such as dendritic cells (DCs), and epithelial cells. Antigen-presenting cells mature in response to interleukin-15 (IL-15) and type I interferon (IFN) produced by stressed epithelial cells, and acquire pro-inflammatory properties; after migration to the draining Peyer’s patch or mesenteric lymph node (MLN), mature DCs present gluten to induce the activation of gluten-specific HLA-DQ2- or HLA-DQ8-restricted CD4+ T cells. Transglutaminase 2 (TG2) and gluten form complexes, which TG2-specific autoreactive B cells can internalize and consequently present gluten peptides on HLA-DQ2 or HLA-DQ8 at their surface.

Don't guess. Get the test.

About Shipping and Processing

Your purchase includes free standard shipping (both ways), lab processing, and a full report with the results of the sample you provide to us.

Lab Processing: Samples are processed in the order they are received.

Standard Reporting: Standard Reporting time is within 10 business days from the date the sample and payment is received by DNA ConneXions.

Rush Report Processing (optional, $99): Rush Report Processing time is guaranteed within 5 business days from the date the sample and payment is received by DNA ConneXions. You can select Rush Processing option on the Checkout page right before entering your payment information.


Important Note Regarding All Tests: In order to return valid test results, it’s critical that directions are followed exactly as they are provided. Failure to do so may yield inaccurate results and a new test will have to be completed. Please be advised that the cost of a new test kit is $50. If you have questions about specimen collection on any of our tests, please visit our FAQ page, or contact us directly: 1-888-843-5832. Thank you!