DNA ConneXions utilizes the molecular technique of PCR to identify opportunistic and pathogenic microbial DNA in oral samples.
Periodontal diseases are silent and chronic inflammatory infections of the oral cavity. These infections can be symptomatic or asymptomatic and can affect the structures around the teeth, including the periodontal ligament and alveolar bone structures.
The bacterial species involved in periodontal diseases are often detected in conjunction with one another within the periodontal pockets. These bacterial species work synergistically to destroy periodontal tissue.
These microbes may ultimately spread to a systemic level, that can contribute to non-oral diseases throughout the body.
Knowledge is Power
The DNA ConnexXions Propensity Panel identifies 19 of the most common bacterial species. This panel not only identifies species involved in periodontal diseases, but also those microbes which have been implicated in the progression of a variety of chronic, systemic conditions.
These disorders include various cancers; such as colorectal, pancreatic, prostate, and breast cancer, and other diseases such as cardiovascular disease, diabetes, cognitive disorders, respiratory issues, and complications relating to pregnancy.
More About Microbes
The microbes selected for the DNA ConneXions Propensity Panel include those pathogens which research shows are possible biological indicators involved in the progression of non-oral diseases.
The presence of these opportunistic pathogens have been demonstrated in various conditions and can likely be of diagnostic value in an individual’s susceptibility of systemic diseases.
Suzuki, N., et al. (2013). Mixed Red-Complex Bacterial Infection in Periodontitis. International Journal of Dentistry.1-6.
Rajesh, K.S., et al. (2013). Poor periodontal health: A cancer risk? J Indian Soc Periodontal. 17(6): 706-710
Shao, J., et al. (2018). Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants. Front Oncol.8:601
Guven, D.C., (2019). Evaluation of cancer risk in patients with periodontal diseases. Turk J Med Sci. 49:826-831
Wong, Sunny H., et al. (2019). Clinical Applications of Gut Microbiota in Cancer Biology. Seminars in Cancer Biology. 55, 28-36.
Hajishengallis, G. and R.J. Lamont. (2012). Beyond the Red Complex and Into More Complexity: the Polymicrobial Synergy and Dysbiosis (PSD) Model of Periodontal Disease Etiology. Molecular Oral Microbiology. 27(6): 409-419.
Bui, F., et al. (2019). Association Between Periodontal Pathogens and Systemic Disease. Biomedical Journal:27-35.
Paddock, C. (n.d.). Mouth Bacteria Linked to Esophageal Cancer. Medical News Today.
Rousee, J. M., et al. (2002). Dialister pneumosintes Associated with Human Brain Abscesses. Journal of Clinical Microbiology, Oct. 3871-3873.
Hashim, N. T. (n.d.). Oral Microbiology in Periodontal Health and Disease. In Oral Microbiology in Periodontitis. doi: http://dx.doi.org/10.5772/intechopen.75709.
Michaud, D.S., et al. (2017) Periodontal Disease, Tooth Loss, and Cancer Risk. Epidemiologic Reviews, Volume 39, Issue 1; 49–58
Mitsuhasi, K., et al. (2015) Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis. Oncotarget; 6(9): 7209–7220.
We are a Biosafety Level 2 Laboratory with a CLIA license encompassing the following specialties: bacteriology, mycology, virology, routine chemistry, and toxicology testing.
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For more information, please contact us: 1.888.843.5832