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1Read our FAQ's.
2 Send us an email, info@dnaconnexions.com
3 Call us 888-843-5832.

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Mon-Fri 9:00AM - 5:00PM
Toll Free: 888-843-5832
Ph: 719-219-2826
Fax: 719-548-8220

Gluten Intolerence

The DNA Connexions Gluten Intolerance test utilizes cheek cells to detect the presence or absence of the HLA tissue typing markers for DQ2 and DQ8 (actually the markers HLA-DQB1*02, HLA-DQA1*0501, HLA-DQB1*0302 exon2 and HLA-DQB1*0302 exon3). The presence of any of these genetic markers is 95% predictive for gluten intolerance/sensitivity. The presence of both markers is 95% predictive for coeliac disease. 

This test can determine whether or not you are at risk for gluten intolerance/sensitivity or coeliac disease before symptoms occur.

Gluten sensitivity is a condition with symptoms similar to those of Celiac disease that improve when gluten is eliminated from the diet. People with gluten sensitivity can experience symptoms such as "foggy mind", depression, ADHD-like behavior, abdominal pain, bloating, diarrhea, constipation, headaches, joint pain, and chronic fatigue when they have gluten in their diet, but other symptoms are also possible. Examples may include asthma-like symptoms upon ingestion of gluten, and/or a filling of the sinus cavities with fluid. While these are common symptoms of Celiac disease, these individuals do not test positive for Celiac disease and/or a wheat allergy.

Individuals who have been diagnosed with gluten sensitivity do not experience the small intestine damage or develop the tissue transglutaminase (tTG) autoantibodies found in celiac disease. Triggers such as viruses, bacteria and possibly gluten itself activate professional antigen-presenting cells, such as dendritic cells (DCs), and epithelial cells. Antigen-presenting cells mature in response to interleukin-15 (IL-15) and type I interferon (IFN) produced by stressed epithelial cells, and acquire pro-inflammatory properties; after migration to the draining Peyer's patch or mesenteric lymph node (MLN), mature DCs present gluten to induce the activation of gluten-specific HLA-DQ2- or HLA-DQ8-restricted CD4+ T cells. Transglutaminase 2 (TG2) and gluten form complexes, which TG2-specific autoreactive B cells can internalize and consequently present gluten peptides on HLA-DQ2 or HLA-DQ8 at their surface.

FULL FORMS REQUIRED FOR  GLUTEN INTOLERANCE HLA GENOTYPING IN TESTING - 
Please call 888-843-5832

TESTS PROVIDED

LYME CONNEX (Lyme Panel)

The DNA Connexions Lyme Panel identifies 3 different Borrelia species and 8 of its common co-infectors. A positive PCR result indicates the presence of spirochete DNA, while negative result does not prove you don’t have Lyme disease.

ORAL CONNEX (Full View)

This test identifies foreign microbial DNA of aerobic and anaerobic bacteria, fungi, viruses and parasites in removed teeth, blood, tissue, implants, bone grafts and other biological samples. This test examines 88 microbes in total.

APOE CONNEX (Apoe Genotyping)

Cheek cells allow us to determine your ability to detoxify mercury, Alzheimer's susceptibility and other autoimmune/ neurological diseases. This test will determine what ApoE genotype you are (2/2, 2/3, 3/3, 3/4, or 4/4).

GLUTEN CONNEX (Gluten Intolerance)

Cheek cells allow us to determine if you have the HLA marker for DQ 2 or DQ 8. The presence of either of these genetic markers is 95% predictive for gluten intolerance/sensitivity. The presence of both markers is 95% predictive.

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